ISDA: 9XZK

Deposition Date 2025-08-27

Release Date 2026-01-28

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9XZK

Keywords:

TRANSFERASE

Title:

Cryo-EM structure of F-box helicase 1 (FBH1) bound to an SCF ubiquitin ligase complex and a 3-way DNA fork (head structure)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.91 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cullin-1
Gene (Uniprot):CUL1
Chain IDs:A (auth: C)
Chain Length:776
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13616 Pfam ID:PF00888, PF26557, PF10557

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase R
Gene (Uniprot):RBX1
Chain IDs:B (auth: R)
Chain Length:108
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62877 Pfam ID:PF12678 EC:2.3.2.27

Ligand Molecules

Primary Citation

Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1.

Greer, B.H, Mendia-Garcia, J, Mullins, E.A, Peacock, E.M, Haigh, S.K, Schiltz, C.J, Aicart-Ramos, C, Tsai, M.S, Cortez, D, Moreno-Herrero, F, Eichman, B.F.Show

Nat Commun 17 ? ? (2026)

PMID: 41587991 DOI: 10.1038/s41467-026-68752-2

Primary Citation of related structures

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