ISDA: 9DNM

Deposition Date 2024-09-17

Release Date 2025-01-22

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9DNM

Keywords:

SIGNALING PROTEIN/Immune System

Title:

Structure of rat beta-arrestin 1 bound to allosteric inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Rattus norvegicus (Taxon ID: 10116)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.47 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-arrestin-1,Soluble cytoc
Gene (Uniprot):Arrb1
Mutagens:M29W, H124I, R128L
Chain IDs:C (auth: A)
Chain Length:494
Number of Molecules:1
Biological Source:Rattus norvegicus

UniProt ID:P29066 Pfam ID:PF00339, PF02752

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:anti-BRIL Fab Heavy chain
Chain IDs:A (auth: H)
Chain Length:225
Number of Molecules:1
Biological Source:Homo sapiens

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:anti-BRIL Fab Light chain
Chain IDs:B (auth: L)
Chain Length:212
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

ODN

Primary Citation

Small-molecule modulation of beta-arrestins.

Kahsai, A.W, Pakharukova, N, Kwon, H.Y, Shah, K.S, Del Real, C.T, Shreiber, B.N, Liang-Lin, J.G, Shim, P.J, Lee, M.A, Ngo, V.A, Schwalb, A.M, Pham, U, Chundi, A, Jiang, H, Flores-Espinoza, E, Liu, S, Nibley, P.C, Bassford, D.K, Hahn, H, Kunzle, C.A, Thomas, B.N, Kim, J, Zhou, Y, Wang, J, Zhang, X, Smith, J.S, Rein, L.A.M, Thomsen, A.R.B, Shenoy, S.K, Rajagopal, S, Shi, L, Ahn, S, Rockman, H.A, Masoudi, A, Lefkowitz, R.J.Show

Nature ? ? ? (2026)

PMID: 42343124 DOI: 10.1038/s41586-026-10683-5

Primary Citation of related structures

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