9DHX image
Deposition Date 2024-09-04
Release Date 2026-03-04
Last Version Date 2026-07-08
Entry Detail
PDB ID:
9DHX
Keywords:
RNA BINDING PROTEIN
Title:
human Argonaute2 R315V/H316A - guide RNA in complex with a fully complementary target
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.10 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9DHX validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Argonaute2 R315V/H316A
Gene (Uniprot):AGO2
Mutagens:R315V, H316A, S387D, S824A, S828D, S831D, S834A
Chain IDs:A
Chain Length:859
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UKV8 Pfam ID:PF16486, PF08699, PF02170, PF16488, PF16487, PF02171 EC:3.1.26.-
Polymer Type:polyribonucleotide
Molecule:guide RNA
Chain IDs:B
Chain Length:20
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polyribonucleotide
Molecule:target RNA
Chain IDs:C
Chain Length:21
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
MG
Primary Citation
Catalytic activation of human Argonaute 2 requires RNA duplex deformation.
Nat.Struct.Mol.Biol. ? ? ? (2026)
PMID: 42342972 DOI: 10.1038/s41594-026-01840-5
Primary Citation of related structures
11GI
11GJ
11GK
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