ISDA: 11GI

Deposition Date 2026-02-23

Release Date 2026-05-13

Last Version Date 2026-07-08

Entry Detail

PDB ID:

11GI

Keywords:

RNA BINDING PROTEIN/RNA

Title:

Human Argonaute2 WT - guide(3 prime-amino) RNA in complex with a fully complementary target

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.00 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Argonaute2 WT
Gene (Uniprot):AGO2
Mutagens:S387D, S824A, S828D, S831D, S834A
Chain IDs:A
Chain Length:859
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UKV8 Pfam ID:PF16486, PF08699, PF02170, PF16488, PF16487, PF02171 EC:3.1.26.-

Polymer Type:polyribonucleotide
Molecule:guide(3 prime-amino) RNA
Chain IDs:B
Chain Length:20
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polyribonucleotide
Molecule:target RNA
Chain IDs:C
Chain Length:23
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

Catalytic activation of human Argonaute 2 requires RNA duplex deformation.

Sarkar, S, Gebert, L.F.R, MacRae, I.J.Show

Nat.Struct.Mol.Biol. ? ? ? (2026)

PMID: 42342972 DOI: 10.1038/s41594-026-01840-5

Primary Citation of related structures

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