ISDA: 11GK

Deposition Date 2026-02-23

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

11GK

Keywords:

RNA BINDING PROTEIN/RNA

Title:

Human Argonaute2 R315V/H316A - guide RNA in complex with a fully complementary target (conformation 2)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.00 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Argonaute-2 R315V/H316A
Gene (Uniprot):AGO2
Mutagens:R315V, H316A, S387D, S824A, S828D, S831D, S834A
Chain IDs:A
Chain Length:859
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UKV8 Pfam ID:PF16486, PF08699, PF02170, PF16488, PF16487, PF02171 EC:3.1.26.-

Polymer Type:polyribonucleotide
Molecule:guide RNA
Chain IDs:B
Chain Length:20
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polyribonucleotide
Molecule:target RNA
Chain IDs:C
Chain Length:23
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

Human Argonaute2 R315V/H316A - miR-122 in complex with a fully complementary target (conformation 2)

Sarkar, S, Gebert, L.F.R, MacRae, I.J.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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