ISDA: 32JY

Deposition Date 2026-07-13

Release Date 2026-09-02

Last Version Date 2026-09-09

Entry Detail

PDB ID:

32JY

Keywords:

TRANSFERASE

Title:

Structure of the pathogenic variant G423S of Human SHMT2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.25

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine hydroxymethyltransfera
Gene (Uniprot):SHMT2
Mutagens:G423S
Chain IDs:A, B, C, D
Chain Length:486
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P34897 Pfam ID:PF00464 EC:2.1.2.1

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
LLP	A	LYS	modified residue

Ligand Molecules

1BO

BU1

EDO

PDO

Primary Citation

Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome

Boumis, G, Breccia, S, Pistoia, G, Spizzichino, S, Zamparelli, C, Troilo, F, Di Matteo, A, Travaglini Allocatelli, C, Contestabile, R, Tramonti, A, Cutruzzola, F, Giardina, G.Show

Front Chem Biol Volume 5 - 2026 ? ? (2026)

Primary Citation of related structures

Feedback Form