32JA image
Deposition Date 2026-07-10
Release Date 2026-09-02
Last Version Date 2026-09-09
Entry Detail
PDB ID:
32JA
Keywords:
Title:
Structure of the pathogenic variant T186R of Human SHMT2 in the apo open dimeric conformation
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.20 Å
R-Value Free:
0.23
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
C 1 2 1
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Isoform 3 of Serine hydroxyme
Gene (Uniprot):SHMT2
Mutagens:T186R
Chain IDs:A
Chain Length:486
Number of Molecules:1
Biological Source:Homo sapiens
Primary Citation
Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome
Front Chem Biol Volume 5 - 2026 ? ? (2026)
Primary Citation of related structures
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