ISDA: 32JD

Deposition Date 2026-07-12

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

32JD

Keywords:

TRANSFERASE

Title:

Structure of the pathogenic variant P157S of Human SHMT2 in a distorted tetrameric conformation

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.70 Å

R-Value Free:

0.25

R-Value Work:

0.25

R-Value Observed:

0.25

Space Group:

P 65 2 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine hydroxymethyltransfera
Gene (Uniprot):SHMT2
Mutagens:P157S
Chain IDs:A, B
Chain Length:486
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P34897 Pfam ID:PF00464 EC:2.1.2.1

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
LLP	A	LYS	modified residue

Ligand Molecules

PO4

Primary Citation

Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome

Giardina, G, Boumis, G, Di Matteo, A, Breccia, S.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form