32JC image
Deposition Date 2026-07-11
Release Date 2026-09-02
Last Version Date 2026-09-02
Entry Detail
PDB ID:
32JC
Keywords:
Title:
Structure of the pathogenic variant T186R of Human SHMT2 in a distorted tetrameric conformation
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
3.07 Å
R-Value Free:
0.38
R-Value Work:
0.35
R-Value Observed:
0.35
Space Group:
P 65 2 2
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Serine hydroxymethyltransfera
Gene (Uniprot):SHMT2
Mutagens:T186R
Chain IDs:A, B
Chain Length:486
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
Primary Citation
Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome
To Be Published ? ? ? (?)
Primary Citation of related structures
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