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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Complex With Compound 15 ((3'R)-1'-(5-Amino-1-Phenyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.66 Å Release Date: 2026-04-01 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6X, NAG |
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N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: A1C6O |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasmakallikrein Inhibitors Complex With Compound 4 ((3'R)-1'-(5-Amino-1-Benzyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Q, NAG |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 25 ((3'R)-1'-{(1P)-5-Amino-1-[2-(Trifluoromethoxy)Phenyl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Z, NAG |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-Amino-1-[(2S)-1,1,1-Trifluorobutan-2-Yl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C7M |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.58 Å Release Date: 2026-02-25 Classification: TRANSFERASE Ligands: FPP, MG |
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Organism: Pseudomonas syringae
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2024-02-28 Classification: TRANSFERASE Ligands: UDP, TRS, EDO |
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Organism: Pseudomonas syringae, Arabidopsis thaliana
Method: X-RAY DIFFRACTION Resolution:2.09 Å Release Date: 2024-02-28 Classification: TRANSFERASE Ligands: UDP, RAM |
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Organism: Pseudomonas syringae, Arabidopsis thaliana
Method: X-RAY DIFFRACTION Resolution:2.85 Å Release Date: 2024-02-28 Classification: TRANSFERASE Ligands: AWU |
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Organism: Pseudomonas syringae, Arabidopsis thaliana
Method: X-RAY DIFFRACTION Resolution:1.29 Å Release Date: 2024-02-28 Classification: TRANSFERASE Ligands: EDO, TRS |
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Vibrio Parahaemolyticus Vtra/Vtrc Complex Bound To The Bile Salt Chenodeoxycholate
Organism: Vibrio parahaemolyticus
Method: X-RAY DIFFRACTION Resolution:2.08 Å Release Date: 2023-06-14 Classification: SIGNALING PROTEIN Ligands: EDO, JN3, PG4, CA |
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Organism: Cellvibrio japonicus (strain ueda107)
Method: X-RAY DIFFRACTION Resolution:1.20 Å Release Date: 2021-07-21 Classification: ELECTRON TRANSPORT Ligands: HEC, NA, EDO |
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Organism: Vibrio parahaemolyticus, Saccharomyces cerevisiae (strain atcc 204508 / s288c)
Method: ELECTRON MICROSCOPY Release Date: 2020-05-20 Classification: TRANSPORT PROTEIN |
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Organism: Vibrio parahaemolyticus, Saccharomyces cerevisiae (strain atcc 204508 / s288c)
Method: ELECTRON MICROSCOPY Release Date: 2020-05-20 Classification: TRANSPORT PROTEIN |
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Organism: Escherichia coli (strain k12)
Method: ELECTRON MICROSCOPY Release Date: 2019-05-15 Classification: MEMBRANE PROTEIN, Toxin |
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Organism: Escherichia coli (strain k12)
Method: ELECTRON MICROSCOPY Release Date: 2019-05-15 Classification: MEMBRANE PROTEIN, Toxin |
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Organism: Escherichia coli (strain k12)
Method: ELECTRON MICROSCOPY Release Date: 2019-05-15 Classification: MEMBRANE PROTEIN, Toxin |
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Engineered Higher-Order Assembly Of Cholera Toxin B Subunits Via The Addition Of C-Terminal Parallel Coiled-Coiled Domains
Organism: Vibrio cholerae
Method: X-RAY DIFFRACTION Resolution:2.45 Å Release Date: 2019-03-20 Classification: TOXIN Ligands: PO4, MPD, CL |
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Organism: Pseudomonas syringae
Method: X-RAY DIFFRACTION Resolution:2.27 Å Release Date: 2018-10-03 Classification: TRANSFERASE Ligands: MG, CA, CL, ANP, EDO, PEG, ACT |
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Organism: Vibrio parahaemolyticus serotype o3:k6 (strain rimd 2210633)
Method: X-RAY DIFFRACTION Resolution:2.70 Å Release Date: 2016-07-20 Classification: SIGNALING PROTEIN Ligands: SO4 |