9ZBA image
Deposition Date 2025-11-20
Release Date 2026-09-09
Last Version Date 2026-11-04
Entry Detail
PDB ID:
9ZBA
Title:
Human GGPPS Bound to Selective Inhibitor CML-07-119 in theShielded Binding Site Conformation
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.15 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Geranylgeranyl pyrophosphate
Gene (Uniprot):GGPS1
Chain IDs:A (auth: B)
Chain Length:301
Number of Molecules:1
Biological Source:Homo sapiens
Primary Citation
Structural and Functional Analysis of GGPPS Inhibition as a Therapeutic Mechanism for Acute Myeloid Leukemia.
J.Med.Chem. 69 21862 21878 (2026)
PMID: 42917932 DOI: 10.1021/acs.jmedchem.6c00808
Primary Citation of related structures
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