9YP8 image
Deposition Date 2025-10-13
Release Date 2026-03-18
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9YP8
Keywords:
CHAPERONE
Title:
Structure of human VCP/p97 dodecamer bound to ADP and UTE-156
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9YP8 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Transitional endoplasmic reti
Gene (Uniprot):VCP
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L
Chain Length:806
Number of Molecules:12
Biological Source:Homo sapiens
UniProt ID:P55072 Pfam ID:PF02359, PF02933, PF00004, PF17862 EC:3.6.4.6
Ligand Molecules
A1CYL
ADP
Primary Citation
Development and Structural Characterization of UTE-156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase.
Adv Sci ? e20545 e20545 (2026)
PMID: 41793187 DOI: 10.1002/advs.202520545
Primary Citation of related structures
9YP6
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