ISDA: 9YP6

Deposition Date 2025-10-13

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9YP6

Keywords:

CHAPERONE

Title:

Structure of human VCP/p97 hexamer bound to ADP and UTE-156

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.80 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transitional endoplasmic reti
Gene (Uniprot):VCP
Chain IDs:A, B, C, D, E, F
Chain Length:806
Number of Molecules:6
Biological Source:Homo sapiens

UniProt ID:P55072 Pfam ID:PF02359, PF02933, PF00004, PF17862 EC:3.6.4.6

Ligand Molecules

A1CYL

ADP

Primary Citation

Development and Structural Characterization of UTE-156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase.

Tamayo-Jaramillo, D, Hegde, S, Jia, X, Coffman, K, Vankayalapati, H, Bearss, D, Jones, K.B, Stark, A.W, Shen, P.S.Show

Adv Sci ? e20545 e20545 (2026)

PMID: 41793187 DOI: 10.1002/advs.202520545

Primary Citation of related structures

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