9Y4T image
Deposition Date 2025-09-03
Release Date 2026-09-16
Last Version Date 2026-09-16
Entry Detail
PDB ID:
9Y4T
Keywords:
MEMBRANE PROTEIN
Title:
V-shaped (channel-formed), ATP-bound, VX809-bound conformation of wild-type human CFTR (composite map from PHENIX based on consensus and local refinement maps from cryoSPARC)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Cricetulus griseus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.14 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9Y4T validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cystic fibrosis transmembrane
Gene (Uniprot):CFTR
Chain IDs:A
Chain Length:1523
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P13569 EC:2.7.4.3
Ligand Molecules
AJP
ATP
CLR
CPL
D12
HEX
MG
MYS
OCT
OLA
P5S
PLM
PTY
VX8
Primary Citation
Nanobody-Driven Stabilization Synergistically Rescues F508del-CFTR and Reveals an Alternative Active State of the Channel
To Be Published ? ? ? (?)
Primary Citation of related structures
9Y4T
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