9XN2 image
Deposition Date 2025-11-12
Release Date 2026-09-30
Last Version Date 2026-09-30
Entry Detail
PDB ID:
9XN2
Keywords:
MEMBRANE PROTEIN/IMMUNE SYSTEM
Title:
Glucagon-like peptide 1 receptor-Gs complex activated by the small molecule agonist SIM1
Biological Source:
Source Organism(s):
Bos taurus (Taxon ID: 9913)
Rattus norvegicus (Taxon ID: 10116)
Lama glama (Taxon ID: 9844)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Trichoplusia ni, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.61 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9XN2 validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Bos taurus
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Rattus norvegicus
UniProt ID:P54311 Pfam ID:PF25391
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C
Chain Length:0
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:P63212 Pfam ID:PF00631
Polymer Type:polypeptide(L)
Molecule:Nanobody 35
Chain IDs:D (auth: N)
Chain Length:0
Number of Molecules:1
Biological Source:Lama glama
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1 recep
Gene (Uniprot):GLP1R
Mutagens:L244I/L360F
Chain IDs:E (auth: R)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P43220 Pfam ID:PF02793, PF00002
Ligand Molecules
A1E0Y
Primary Citation
Structural basis for small-molecule agonism at GCGR and GIPR via a conserved intracellular allosteric site.
Acta Pharmacol.Sin. ? ? ? (2026)
PMID: 42736455 DOI: 10.1038/s41401-026-01923-5
Primary Citation of related structures
9XN2
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