ISDA: 9SYO

Deposition Date 2025-10-13

Release Date 2026-10-28

Last Version Date 2026-10-28

Entry Detail

PDB ID:

9SYO

Keywords:

CHAPERONE

Title:

Crystal structure of human Hsp90-alpha NBD(aa9-236)in complex with dual chaperon targeting ligand THOR-1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.29 Å

R-Value Free:

0.18

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 21 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Heat shock protein HSP 90-alp
Gene (Uniprot):HSP90AA1
Chain IDs:A, B
Chain Length:228
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P07900 EC:3.6.4.10

Ligand Molecules

A1JR1

Primary Citation

Unlocking Dual Targeting: Fragment-Growing towards simultaneous Inhibition of Hsc70 and Hsp90

Zehe, M, Brenner, M, Bothe, S, Marzouk, M, Gehrig, T, Schindelin, H, Sotriffer, C.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form