ISDA: 9SYP

Deposition Date 2025-10-13

Release Date 2026-10-28

Last Version Date 2026-10-28

Entry Detail

PDB ID:

9SYP

Keywords:

CHAPERONE

Title:

Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with dual chaperon targeting ligand THOR-1

Biological Source:

Source Organism(s):

Bos taurus (Taxon ID: 9913)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.97 Å

R-Value Free:

0.26

R-Value Work:

0.22

R-Value Observed:

0.23

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Heat shock cognate 71 kDa pro
Gene (Uniprot):HSPA8
Mutagens:E213A, D214A
Chain IDs:A
Chain Length:554
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P19120

Ligand Molecules

A1JR1

EPE

GOL

Primary Citation

Unlocking Dual Targeting: Fragment-Growing towards simultaneous Inhibition of Hsc70 and Hsp90

Zehe, M, Brenner, M, Bothe, S, Marzouk, M, Gehrig, T, Schindelin, H, Sotriffer, C.Show

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Primary Citation of related structures

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