9SVH image
Deposition Date 2025-10-03
Release Date 2026-10-14
Last Version Date 2026-10-14
Entry Detail
PDB ID:
9SVH
Keywords:
LIGASE
Title:
Cryo-EM structure of CRBN bound to 1-[1-(4-piperidyl)indol-4-yl]hexahydropyrimidine-2,4-dione in the closed conformation
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Trichoplusia ni
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.66 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9SVH validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Gene (Uniprot):DDB1
Chain IDs:A
Chain Length:836
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q16531
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein cereblon
Gene (Uniprot):CRBN
Chain IDs:B
Chain Length:442
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96SW2
Ligand Molecules
A1JP8
ZN
Primary Citation
Structural and Biophysical Methods for the Assessment of Cereblon Binders for PROTACs
To Be Published ? ? ? (?)
Primary Citation of related structures
9SVH
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