9SJ4 image
Deposition Date 2025-08-29
Release Date 2026-11-04
Last Version Date 2026-11-04
Entry Detail
PDB ID:
9SJ4
Keywords:
TRANSLATION
Title:
Structure of a circMbl 48S translation initiation complex in the scanning state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Saccharomyces cerevisiae (Taxon ID: 4932)
Drosophila melanogaster (Taxon ID: 7227)
Expression System(s):
Escherichia coli bl21(de3), Saccharomyces cerevisiae
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.10 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9SJ4 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3K
Chain IDs:WA (auth: 3)
Chain Length:218
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UBQ5
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3F
Chain IDs:UA (auth: 4)
Chain Length:357
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00303 EC:3.4.19.12
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3L
Chain IDs:BB (auth: 5)
Chain Length:564
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y262
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3M
Chain IDs:TA (auth: 6)
Chain Length:374
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q7L2H7
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3G
Chain IDs:Y (auth: 7)
Chain Length:320
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O75821
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3H
Chain IDs:VA (auth: 8)
Chain Length:352
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O15372
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L41
Gene (Uniprot):RPL41
Chain IDs:Z (auth: 9)
Chain Length:25
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62945
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3A
Chain IDs:A
Chain Length:1382
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q14152
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3E
Chain IDs:B
Chain Length:445
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P60228
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF2S1
Chain IDs:C (auth: D)
Chain Length:315
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P05198 EC:3.6.5.3
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF2S3
Chain IDs:D (auth: E)
Chain Length:472
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P41091 EC:3.6.5.3
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3I
Chain IDs:E (auth: F)
Chain Length:325
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13347
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF1AX
Chain IDs:F (auth: G)
Chain Length:147
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P47813
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF1
Chain IDs:G (auth: H)
Chain Length:116
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P41567
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3B
Chain IDs:H (auth: I)
Chain Length:814
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P55884
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3C
Chain IDs:I (auth: J)
Chain Length:913
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q99613
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S7
Gene (Uniprot):RPS7
Chain IDs:J (auth: L)
Chain Length:194
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62081
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S27
Gene (Uniprot):RPS27
Chain IDs:K (auth: M)
Chain Length:84
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P42677
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S21
Gene (Uniprot):RPS21
Chain IDs:L (auth: N)
Chain Length:83
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P63220
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S2
Gene (Uniprot):RPS2
Chain IDs:M (auth: O)
Chain Length:293
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P15880
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3a
Gene (Uniprot):RPS3A
Chain IDs:N (auth: P)
Chain Length:264
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P61247
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein SA
Gene (Uniprot):RPSA
Chain IDs:O (auth: Q)
Chain Length:295
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P08865
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S26
Gene (Uniprot):RPS26
Chain IDs:P (auth: R)
Chain Length:115
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62854
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S6
Gene (Uniprot):RPS6
Chain IDs:Q (auth: S)
Chain Length:249
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62753
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S14
Gene (Uniprot):RPS14
Chain IDs:R (auth: T)
Chain Length:151
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62263
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF2S2
Chain IDs:S (auth: U)
Chain Length:333
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P20042 EC:3.6.5.3
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S13
Gene (Uniprot):RPS13
Chain IDs:T (auth: V)
Chain Length:151
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62277
Polymer Type:polyribonucleotide
Molecule:18S rRNA
Chain IDs:U (auth: W)
Chain Length:1869
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S11
Gene (Uniprot):RPS11
Chain IDs:V (auth: X)
Chain Length:158
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62280
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS4X
Chain IDs:W (auth: Y)
Chain Length:263
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62701
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S9
Gene (Uniprot):RPS9
Chain IDs:X (auth: Z)
Chain Length:194
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P46781
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S23
Gene (Uniprot):RPS23
Chain IDs:AA (auth: a)
Chain Length:143
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62266
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S30
Gene (Uniprot):FAU
Chain IDs:BA (auth: b)
Chain Length:59
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62861
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S15a
Gene (Uniprot):RPS15A
Chain IDs:CA (auth: c)
Chain Length:130
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62244
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S8
Gene (Uniprot):RPS8
Chain IDs:DA (auth: d)
Chain Length:208
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62241
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S24
Gene (Uniprot):RPS24
Chain IDs:EA (auth: e)
Chain Length:133
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62847
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S5
Gene (Uniprot):RPS5
Chain IDs:FA (auth: f)
Chain Length:204
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P46782
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S16
Gene (Uniprot):RPS16
Chain IDs:GA (auth: g)
Chain Length:146
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62249
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3
Gene (Uniprot):RPS3
Chain IDs:HA (auth: h)
Chain Length:243
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P23396 EC:4.2.99.18
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S10
Gene (Uniprot):RPS10
Chain IDs:IA (auth: i)
Chain Length:165
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P46783
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S15
Gene (Uniprot):RPS15
Chain IDs:JA (auth: j)
Chain Length:145
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62841
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Receptor of activated protein
Gene (Uniprot):RACK1
Chain IDs:KA (auth: k)
Chain Length:317
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P63244
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S19
Gene (Uniprot):RPS19
Chain IDs:XA (auth: l)
Chain Length:145
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P39019
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S25
Gene (Uniprot):RPS25
Chain IDs:LA (auth: m)
Chain Length:125
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62851
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S18
Gene (Uniprot):RPS18
Chain IDs:ZA (auth: n)
Chain Length:152
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62269
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S29
Gene (Uniprot):RPS29
Chain IDs:MA (auth: o)
Chain Length:56
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62273
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-ribosomal protein e
Gene (Uniprot):RPS27A
Chain IDs:NA (auth: p)
Chain Length:80
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62979
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S12
Gene (Uniprot):RPS12
Chain IDs:OA (auth: q)
Chain Length:132
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P25398
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S28
Gene (Uniprot):RPS28
Chain IDs:PA (auth: s)
Chain Length:69
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62857
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S17
Gene (Uniprot):RPS17
Chain IDs:QA (auth: v)
Chain Length:135
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P08708
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S20
Gene (Uniprot):RPS20
Chain IDs:RA (auth: w)
Chain Length:119
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P60866
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):EIF3D
Chain IDs:SA (auth: x)
Chain Length:548
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O15371
Polymer Type:polyribonucleotide
Molecule:tRNAi-Met
Chain IDs:YA (auth: y)
Chain Length:75
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae
Polymer Type:polyribonucleotide
Molecule:circMbl-FLAG
Chain IDs:AB (auth: z)
Chain Length:774
Number of Molecules:1
Biological Source:Drosophila melanogaster
Ligand Molecules
K
MG
ZN
Primary Citation
Mechanism of translation initiation on endogenous eukaryotic circular RNAs
To Be Published ? ? ? (?)
Primary Citation of related structures
9SJ3
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