9RVU image
Deposition Date 2025-07-09
Release Date 2026-04-01
Last Version Date 2026-07-22
Entry Detail
PDB ID:
9RVU
Keywords:
Title:
in situ S. pombe hibernating ribosome after 7 days of glucose depletion
Biological Source:
Source Organism(s):
Method Details:
Experimental Method:
Resolution:
3.38 Å
Aggregation State:
CELL
Reconstruction Method:
SUBTOMOGRAM AVERAGING
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1701
Chain IDs:EC (auth: A)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polyribonucleotide
Molecule:18S small subunit ribosomal R
Chain IDs:A (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps001
Chain IDs:B (auth: AD)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps102
Chain IDs:C (auth: AE)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2
Chain IDs:D (auth: AF)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps3
Chain IDs:E (auth: AG)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps403
Chain IDs:F (auth: AH)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps5
Chain IDs:G (auth: AI)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps602
Chain IDs:H (auth: AJ)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps7
Chain IDs:I (auth: AK)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps802
Chain IDs:J (auth: AL)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps902
Chain IDs:K (auth: AM)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1002
Chain IDs:L (auth: AN)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1101
Chain IDs:M (auth: AO)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1201
Chain IDs:N (auth: AP)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps13
Chain IDs:O (auth: AQ)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1401
Chain IDs:P (auth: AR)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1502
Chain IDs:Q (auth: AS)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1601
Chain IDs:R (auth: AT)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1701
Chain IDs:S (auth: AU)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1801
Chain IDs:T (auth: AV)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1901
Chain IDs:U (auth: AW)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps20
Chain IDs:V (auth: Aa)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps21
Chain IDs:W (auth: Ab)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2201
Chain IDs:X (auth: Ac)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps23
Chain IDs:Y (auth: Ad)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2401
Chain IDs:Z (auth: Ae)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2502
Chain IDs:AA (auth: Af)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2602
Chain IDs:BA (auth: Ag)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps27
Chain IDs:CA (auth: Ah)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2801
Chain IDs:DA (auth: Ai)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps29
Chain IDs:EA (auth: Aj)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps3001
Chain IDs:FA (auth: Ak)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):cpc2
Chain IDs:GA (auth: Am)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl42
Chain IDs:HA (auth: B0)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl4301
Chain IDs:IA (auth: B1)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polyribonucleotide
Molecule:28S large subunit ribosomal R
Chain IDs:JA (auth: B2)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polyribonucleotide
Molecule:5S large subunit ribosomal RN
Chain IDs:KA (auth: B3)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polyribonucleotide
Molecule:5.8S large subunit ribosomal
Chain IDs:LA (auth: B4)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):ubi1
Chain IDs:BC (auth: BA)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl801
Chain IDs:MA (auth: BN)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl301
Chain IDs:NA (auth: BO)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl402
Chain IDs:OA (auth: BP)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl502
Chain IDs:PA (auth: BQ)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl6
Chain IDs:QA (auth: BR)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl701
Chain IDs:RA (auth: BS)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl8
Chain IDs:SA (auth: BT)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl902
Chain IDs:CC (auth: BU)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1001
Chain IDs:TA (auth: BV)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1101
Chain IDs:UA (auth: BW)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl13
Chain IDs:VA (auth: BX)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl14
Chain IDs:WA (auth: BY)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1502
Chain IDs:XA (auth: BZ)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1602
Chain IDs:YA (auth: Ba)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1701
Chain IDs:DC (auth: Bb)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1802
Chain IDs:ZA (auth: Bc)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1902
Chain IDs:AB (auth: Bd)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2001
Chain IDs:BB (auth: Be)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2102
Chain IDs:CB (auth: Bf)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl22
Chain IDs:DB (auth: Bg)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2301
Chain IDs:EB (auth: Bh)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2402
Chain IDs:FB (auth: Bi)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2501
Chain IDs:GB (auth: Bj)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl26
Chain IDs:HB (auth: Bk)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2701
Chain IDs:IB (auth: Bl)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2801
Chain IDs:JB (auth: Bm)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl29
Chain IDs:KB (auth: Bn)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3001
Chain IDs:LB (auth: Bo)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl31
Chain IDs:MB (auth: Bp)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3202
Chain IDs:NB (auth: Bq)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl35b
Chain IDs:OB (auth: Br)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3402
Chain IDs:PB (auth: Bs)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl35
Chain IDs:QB (auth: Bt)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3602
Chain IDs:RB (auth: Bu)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3702
Chain IDs:SB (auth: Bv)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3801
Chain IDs:TB (auth: Bw)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl39
Chain IDs:UB (auth: Bx)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl44
Chain IDs:VB (auth: By)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Ribosome-associated protein o
Gene (Uniprot):oga1
Chain IDs:WB (auth: H1)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Elongation factor 2
Gene (Uniprot):eft201, eft202
Chain IDs:XB (auth: HE)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Gene (Uniprot):tif51a
Chain IDs:AC (auth: HI)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl101
Chain IDs:YB (auth: HL)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polypeptide(L)
Molecule:SDO1-like protein C21C3.19
Gene (Uniprot):SPBC21C3.19
Chain IDs:ZB (auth: HS)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
5CT AC LYS modified residue
Ligand Molecules
Primary Citation
SNOR promotes translation restart after dormancy.
Nature 655 516 524 (2026)
PMID: 42129552 DOI: 10.1038/s41586-026-10530-7

Abstact

Cellular dormancy enables survival during prolonged nutrient limitation by reversibly suppressing protein synthesis(1-4). How inactive eukaryotic ribosomes are reactivated when nutrients return remains unclear. Here, using high-resolution in situ cryo-electron tomography in Schizosaccharomyces pombe, we identify SNOR, an SBDS domain-containing ribosome-associated factor that binds at the peptidyl transferase centre and contacts the hypusinated loop of eIF5A during glucose depletion-induced dormancy. Rather than acting as a canonical hibernation factor, SNOR licenses dormant ribosomes for rapid translational restart. Upon glucose repletion, SNOR and eIF5A act together to promote efficient recovery of polysomes and exit from dormancy. These findings define a stress-responsive ribosome restart module that couples carbon-source limitation to surveillance of the ribosomal active site and reactivation of protein synthesis.

Legend

Protein

Chemical

Disease

Primary Citation of related structures
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