ISDA: 9QQS

Deposition Date 2025-04-02

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9QQS

Keywords:

MEMBRANE PROTEIN

Title:

Structure of the MEGF8-MOSMO complex with nanobody 270 (Focused refinement)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)

Expression System(s):

Homo sapiens, Escherichia coli k-12

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.65 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Modulator of smoothened prote
Gene (Uniprot):MOSMO
Chain IDs:A
Chain Length:211
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8NHV5 Pfam ID:PF18800

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2 of Multiple epiderm
Chain IDs:B
Chain Length:477
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q7Z7M0

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nanobody 270
Chain IDs:C
Chain Length:129
Number of Molecules:1
Biological Source:Lama glama

Ligand Molecules

A1JAX

PLM

Primary Citation

Design principles of a membrane-spanning ubiquitin ligase

Williams, C, Nocka, L.M, Hedger, G, Carrique, L, Pusapati, G.V, Parashara, P, Latorraca, N, Sarkar, P, Lartey, D, Gao, L, Pardon, E, Milenkovic, L, Steyaert, J, Chalk, R, Bazan, F, Rouse, S.L, Marqusee, S, Kong, J.H, Siebold, C, Rohatgi, R.Show

Mol Cell ? ? ? (2026)

DOI: 10.1016/j.molcel.2026.05.001

Primary Citation of related structures

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