9PI5 image
Deposition Date 2025-07-10
Release Date 2026-04-15
Last Version Date 2026-04-15
Entry Detail
PDB ID:
9PI5
Keywords:
DNA BINDING PROTEIN/DNA
Title:
Poly dA bound form of Single stranded DNA-binding protein(ICP8) from Herpes simplex virus-1. Mutations: C254S, C455S
Biological Source:
Source Organism(s):
Human alphaherpesvirus 1 (Taxon ID: 10298)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.00 Å
R-Value Free:
0.23
R-Value Work:
0.19
Space Group:
P 32 2 1
9PI5 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Major DNA-binding protein
Gene (Uniprot):DBP
Mutagens:C254S, C455S
Chain IDs:A
Chain Length:1127
Number of Molecules:1
Biological Source:Human alphaherpesvirus 1
UniProt ID:P04296 Pfam ID:PF00747
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*AP*AP*AP*AP*AP*AP
Chain IDs:B (auth: G)
Chain Length:8
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
NA
Primary Citation
The crystal structure of the herpes virus ICP8 protein in complex with single-stranded DNA reveals the molecular determinants of nucleotide recognition.
J. Biol. Chem. ? 111366 111366 (2026)
PMID: 41833734 DOI: 10.1016/j.jbc.2026.111366
Primary Citation of related structures
9PI5
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