9EHD image
Deposition Date 2024-11-22
Release Date 2026-01-07
Last Version Date 2026-07-22
Entry Detail
PDB ID:
9EHD
Keywords:
PROTEIN BINDING
Title:
Crystal structure of N-SH2 domain of SHP2 bound to GAB1 tyrosine phosphorylated peptide (624-633) QVEpYLDLDLD
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.59 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 43 21 2
9EHD validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 1 of Tyrosine-protein
Gene (Uniprot):PTPN11
Chain IDs:A
Chain Length:109
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q06124 Pfam ID:PF00017 EC:3.1.3.48
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Phosphorylated peptide from G
Gene (Uniprot):GAB1
Chain IDs:B
Chain Length:10
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13480
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
PTR B TYR modified residue
Primary Citation
Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling.
Proc.Natl.Acad.Sci.USA 123 e2513851123 e2513851123 (2026)
PMID: 41528873 DOI: 10.1073/pnas.2513851123
Primary Citation of related structures
9EHA
9EH9
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