9EH9 image
Deposition Date 2024-11-22
Release Date 2026-01-07
Last Version Date 2026-07-22
Entry Detail
PDB ID:
9EH9
Keywords:
PROTEIN BINDING
Title:
Crystal structure of unbound N-SH2 domain of SHP2
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.83 Å
R-Value Free:
0.25
R-Value Work:
0.22
R-Value Observed:
0.23
Space Group:
P 43 21 2
9EH9 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 1 of Tyrosine-protein
Gene (Uniprot):PTPN11
Chain IDs:A
Chain Length:109
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q06124 Pfam ID:PF00017 EC:3.1.3.48
Ligand Molecules
ACY
Primary Citation
Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling.
Proc.Natl.Acad.Sci.USA 123 e2513851123 e2513851123 (2026)
PMID: 41528873 DOI: 10.1073/pnas.2513851123
Primary Citation of related structures
9EH9
Feedback Form
Name
Email
Institute
Feedback