ISDA: 9EHA

Deposition Date 2024-11-22

Release Date 2026-01-07

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9EHA

Keywords:

PROTEIN BINDING

Title:

Crystal structure of N-SH2 domain of SHP2 bound to phosphotyrosine

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.71 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 43 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 1 of Tyrosine-protein
Gene (Uniprot):PTPN11
Chain IDs:A
Chain Length:109
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q06124 Pfam ID:PF00017 EC:3.1.3.48

Ligand Molecules

PTR

SO4

Primary Citation

Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling.

Glaser, A.W, Padua, R.A.P, Ojoawo, A.M, Sullivan, C, Kern, D.Show

Proc.Natl.Acad.Sci.USA 123 e2513851123 e2513851123 (2026)

PMID: 41528873 DOI: 10.1073/pnas.2513851123

Primary Citation of related structures

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