9DZK image
Deposition Date 2024-10-16
Release Date 2026-01-21
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9DZK
Title:
Human GC-A bound to REGN5308
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.90 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Atrial natriuretic peptide re
Gene (Uniprot):NPR1
Chain IDs:A (auth: B), D (auth: A)
Chain Length:1031
Number of Molecules:2
Biological Source:Homo sapiens
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:REGN5308 - Heavy chain
Chain IDs:B (auth: H)
Chain Length:227
Number of Molecules:1
Biological Source:Mus musculus
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:REGN5308 - Light chain
Chain IDs:C (auth: L)
Chain Length:213
Number of Molecules:1
Biological Source:Mus musculus
Primary Citation
Structural insights into single-pass transmembrane receptor GC-A activation by distinct antihypertensive antibodies.
Nat Commun 17 ? ? (2026)
PMID: 41942428 DOI: 10.1038/s41467-026-71594-7
Primary Citation of related structures
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