ISDA: 9DZG

Deposition Date 2024-10-16

Release Date 2026-01-21

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9DZG

Keywords:

MEMBRANE PROTEIN

Title:

Human GC-A bound to XX16

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.30 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Atrial natriuretic peptide re
Gene (Uniprot):NPR1
Chain IDs:A, B
Chain Length:1029
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P16066 Pfam ID:PF01094, PF07714, PF00211 EC:4.6.1.2

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:XX16 - Heavy Chain
Chain IDs:C (auth: H)
Chain Length:228
Number of Molecules:1
Biological Source:Mus musculus

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:XX16 - Light chain
Chain IDs:D (auth: L)
Chain Length:214
Number of Molecules:1
Biological Source:Mus musculus

Ligand Molecules

Primary Citation

Structural insights into single-pass transmembrane receptor GC-A activation by distinct antihypertensive antibodies.

Liu, S, Manzo, O, Wang, J, Zhu, L, Xiao, F, Su, Y.C, Kurre, D, Liu, W, Miao, Y, Di Lorenzo, A, Huang, X.Y.Show

Nat Commun 17 ? ? (2026)

PMID: 41942428 DOI: 10.1038/s41467-026-71594-7

Primary Citation of related structures

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