ISDA: 7ZJX

Deposition Date 2022-04-12

Release Date 2022-09-07

Last Version Date 2026-06-24

Entry Detail

PDB ID:

7ZJX

Keywords:

RIBOSOME

Title:

Rabbit 80S ribosome programmed with SECIS and SBP2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Cricket paralysis virus (Taxon ID: 12136)
Rattus norvegicus (Taxon ID: 10116)
Oryctolagus cuniculus (Taxon ID: 9986)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Selenocysteine insertion sequ
Gene (Uniprot):SECISBP2
Chain IDs:A (auth: B)
Chain Length:854
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96T21 Pfam ID:PF01248

Polymer Type:polyribonucleotide
Molecule:CrPV IRES
Chain IDs:B (auth: I)
Chain Length:163
Number of Molecules:1
Biological Source:Cricket paralysis virus

Polymer Type:polyribonucleotide
Molecule:28S rRNA
Chain IDs:C (auth: L5)
Chain Length:4808
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Polymer Type:polyribonucleotide
Molecule:5S rRNA
Chain IDs:D (auth: L7)
Chain Length:120
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Polymer Type:polyribonucleotide
Molecule:5.8S rRNA
Chain IDs:E (auth: L8)
Chain Length:158
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein uL2
Gene (Uniprot):RPL8
Chain IDs:F (auth: LD)
Chain Length:257
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A8B8VPA8 Pfam ID:PF00181, PF03947

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein uL3
Gene (Uniprot):RPL3
Chain IDs:G (auth: LE)
Chain Length:403
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TL06 Pfam ID:PF00297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L4
Gene (Uniprot):RPL4
Chain IDs:H (auth: LF)
Chain Length:413
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SVW5 Pfam ID:PF00573, PF14374

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal_L18_c domain-contai
Chain IDs:I (auth: LG)
Chain Length:297
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:P19949 Pfam ID:PF17144, PF14204

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L6
Gene (Uniprot):RPL6
Chain IDs:J (auth: LH)
Chain Length:291
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SKF7 Pfam ID:PF03868, PF01159

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal Protein uL30
Gene (Uniprot):HJG63_016928
Chain IDs:K (auth: LI)
Chain Length:247
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A7J8C453 Pfam ID:PF08079, PF00327

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein eL8
Gene (Uniprot):RPL7A
Chain IDs:L (auth: LJ)
Chain Length:266
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:P62424 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L9
Gene (Uniprot):RPL9
Chain IDs:M (auth: LK)
Chain Length:192
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SWI6 Pfam ID:PF00347

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L10
Gene (Uniprot):RPL10
Chain IDs:N (auth: LL)
Chain Length:214
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:B7NZQ2 Pfam ID:PF00252

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L11
Gene (Uniprot):RPL11
Chain IDs:O (auth: LM)
Chain Length:178
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TUB8 Pfam ID:PF00281, PF00673

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein eL13
Gene (Uniprot):RPL13
Chain IDs:P (auth: LO)
Chain Length:211
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TKB3 Pfam ID:PF01294

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L14
Gene (Uniprot):RPL14
Chain IDs:Q (auth: LP)
Chain Length:218
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SZ12 Pfam ID:PF01929

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L15
Gene (Uniprot):RPL15
Chain IDs:R (auth: LQ)
Chain Length:204
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1T0C1 Pfam ID:PF00827

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein uL13
Gene (Uniprot):RPL13A
Chain IDs:S (auth: LR)
Chain Length:203
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A0N8ETI8 Pfam ID:PF00572

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein uL22
Gene (Uniprot):Rpl17
Chain IDs:T (auth: LS)
Chain Length:184
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A8J4KQ25 Pfam ID:PF00237

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal Protein eL18
Gene (Uniprot):RPL18
Chain IDs:U (auth: LT)
Chain Length:188
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:F6QKI9 Pfam ID:PF17135

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L19
Gene (Uniprot):CK820_G0039174
Chain IDs:V (auth: LU)
Chain Length:196
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A2J8KH59 Pfam ID:PF01280

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein eL20
Chain IDs:W (auth: LV)
Chain Length:176
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A1Z5LHJ5 Pfam ID:PF01775

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L21
Gene (Uniprot):RPL21
Chain IDs:X (auth: LW)
Chain Length:160
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SHQ2 Pfam ID:PF01157

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein eL22
Gene (Uniprot):RPL22
Chain IDs:Y (auth: LX)
Chain Length:128
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:Q4R5I3 Pfam ID:PF01776

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L23
Chain IDs:Z (auth: LY)
Chain Length:140
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A3P9HH38 Pfam ID:PF00238

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L24
Gene (Uniprot):RPL24
Chain IDs:AA (auth: LZ)
Chain Length:157
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SE28 Pfam ID:PF01246

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal_L23eN domain-contai
Gene (Uniprot):RPL23A
Chain IDs:BA (auth: La)
Chain Length:156
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SE76 Pfam ID:PF03939, PF00276

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L26
Gene (Uniprot):FD755_020861
Chain IDs:CA (auth: Lb)
Chain Length:145
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A5N3X333 Pfam ID:PF16906, PF00467

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27
Gene (Uniprot):Rpl27
Chain IDs:DA (auth: Lc)
Chain Length:136
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A851LWS6 Pfam ID:PF00467, PF01777

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27a
Gene (Uniprot):RPL27A
Chain IDs:EA (auth: Ld)
Chain Length:148
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SNY0 Pfam ID:PF00828

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L29
Gene (Uniprot):RPL29
Chain IDs:FA (auth: Le)
Chain Length:245
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SGR6 Pfam ID:PF01779

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L30
Gene (Uniprot):RPL30
Chain IDs:GA (auth: Lf)
Chain Length:115
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TDL2 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L31
Gene (Uniprot):RPL31
Chain IDs:HA (auth: Lg)
Chain Length:125
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SHG0 Pfam ID:PF01198

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L32
Chain IDs:IA (auth: Lh)
Chain Length:135
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TUN8 Pfam ID:PF01655

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L35a
Gene (Uniprot):RPL35A
Chain IDs:JA (auth: Li)
Chain Length:110
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SF08 Pfam ID:PF01247

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L34
Gene (Uniprot):RPL34
Chain IDs:KA (auth: Lj)
Chain Length:117
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TXG5 Pfam ID:PF01199

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L35
Gene (Uniprot):RPL35
Chain IDs:LA (auth: Lk)
Chain Length:123
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SIT5 Pfam ID:PF00831

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L36
Gene (Uniprot):Rpl36
Chain IDs:MA (auth: Ll)
Chain Length:105
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A1S3FQR5 Pfam ID:PF01158

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L37
Gene (Uniprot):RPL37
Chain IDs:NA (auth: Lm)
Chain Length:97
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:U3KPD5 Pfam ID:PF01907

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L38
Gene (Uniprot):RPL38
Chain IDs:OA (auth: Ln)
Chain Length:70
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A1A7W9T9 Pfam ID:PF01781

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein eL39
Gene (Uniprot):LOC100343258
Chain IDs:PA (auth: Lo)
Chain Length:51
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TTN1 Pfam ID:PF00832

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L40
Gene (Uniprot):UBA52
Chain IDs:QA (auth: Lp)
Chain Length:128
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A8C8Y9V5 Pfam ID:PF00240, PF01020

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein eL42
Gene (Uniprot):mPipKuh1_015125
Chain IDs:RA (auth: Lq)
Chain Length:106
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A7J7V6K8 Pfam ID:PF00935

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein eL43
Gene (Uniprot):RPL37A
Chain IDs:SA (auth: Lr)
Chain Length:92
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A6I9ZMF9 Pfam ID:PF01780

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein eL28
Gene (Uniprot):EI555_020534
Chain IDs:TA (auth: Ls)
Chain Length:137
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A4U1EJN3 Pfam ID:PF01778

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein
Gene (Uniprot):RPL10A
Chain IDs:UA (auth: Lx)
Chain Length:217
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SKZ8 Pfam ID:PF00687

Polymer Type:polyribonucleotide
Molecule:GPX4 SECIS element
Chain IDs:VA (auth: S)
Chain Length:855
Number of Molecules:1
Biological Source:Rattus norvegicus

Polymer Type:polyribonucleotide
Molecule:18S rRNA
Chain IDs:WA (auth: S2)
Chain Length:1870
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S27
Gene (Uniprot):HJG63_016964
Chain IDs:XA (auth: SB)
Chain Length:84
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A7J8BG50 Pfam ID:PF01667

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S28
Gene (Uniprot):DUI87_22462
Chain IDs:YA (auth: SC)
Chain Length:69
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A3M0JHZ8 Pfam ID:PF01200

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin carboxyl extension
Gene (Uniprot):RPS27A
Chain IDs:ZA (auth: SD)
Chain Length:156
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A8C0T835 Pfam ID:PF00240, PF01599

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S30
Gene (Uniprot):FAU
Chain IDs:AB (auth: SE)
Chain Length:133
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1T8A2 Pfam ID:PF00240, PF04758

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein eS26
Chain IDs:BB (auth: SF)
Chain Length:115
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A2K5LQY6 Pfam ID:PF01283

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):RACK1
Chain IDs:CB (auth: SG)
Chain Length:317
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A2K6K8B0 Pfam ID:PF00400

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S29
Gene (Uniprot):RPS29
Chain IDs:DB (auth: SH)
Chain Length:56
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1U7M4 Pfam ID:PF00253

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein SA
Gene (Uniprot):RPSA
Chain IDs:EB (auth: SL)
Chain Length:295
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TLT8 Pfam ID:PF00318, PF16122

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3a
Gene (Uniprot):RPS3A
Chain IDs:FB (auth: SM)
Chain Length:264
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SS70 Pfam ID:PF01015

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein uS5
Gene (Uniprot):RPS2
Chain IDs:GB (auth: SN)
Chain Length:293
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:O18789 Pfam ID:PF00333, PF03719

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3
Gene (Uniprot):RPS3
Chain IDs:HB (auth: SO)
Chain Length:281
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TNM3 Pfam ID:PF07650, PF00189 EC:4.2.99.18

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S4
Gene (Uniprot):RPS4X
Chain IDs:IB (auth: SP)
Chain Length:263
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:Q76N24 Pfam ID:PF08071, PF00900, PF00467, PF16121

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein S5
Gene (Uniprot):RPS5
Chain IDs:JB (auth: SQ)
Chain Length:204
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A5F9DBR8 Pfam ID:PF00177

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S6
Gene (Uniprot):RPS6
Chain IDs:KB (auth: SR)
Chain Length:249
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:P62753 Pfam ID:PF01092

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S7
Gene (Uniprot):RPS7
Chain IDs:LB (auth: SS)
Chain Length:432
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SVB0 Pfam ID:PF01251

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S8
Gene (Uniprot):RPS8
Chain IDs:MB (auth: ST)
Chain Length:208
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:Q5E958 Pfam ID:PF01201

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S9
Gene (Uniprot):RPS9
Chain IDs:NB (auth: SU)
Chain Length:194
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:B7NZS8 Pfam ID:PF00163, PF01479

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:S10_plectin domain-containing
Chain IDs:OB (auth: SV)
Chain Length:165
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TPV3 Pfam ID:PF03501

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S11
Gene (Uniprot):RPS11
Chain IDs:PB (auth: SW)
Chain Length:158
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TRM4 Pfam ID:PF16205, PF00366

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S12
Gene (Uniprot):RPS12
Chain IDs:QB (auth: SX)
Chain Length:132
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SFR8 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S13
Gene (Uniprot):RPS13
Chain IDs:RB (auth: SY)
Chain Length:151
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A663F1C0 Pfam ID:PF08069, PF00312

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein uS11
Gene (Uniprot):Rps14
Chain IDs:SB (auth: SZ)
Chain Length:151
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A7L0BEC6 Pfam ID:PF00411

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S15
Gene (Uniprot):RPS15
Chain IDs:TB (auth: Sa)
Chain Length:145
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1U0Q2 Pfam ID:PF00203

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein uS9
Gene (Uniprot):RPS16
Chain IDs:UB (auth: Sb)
Chain Length:172
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SGX4 Pfam ID:PF00380

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S17
Gene (Uniprot):RPS17
Chain IDs:VB (auth: Sc)
Chain Length:135
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TU13 Pfam ID:PF00833

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S18
Gene (Uniprot):RPS18
Chain IDs:WB (auth: Sd)
Chain Length:152
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:H0WTR0 Pfam ID:PF00416

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S Ribosomal protein eS19
Gene (Uniprot):RPS19
Chain IDs:XB (auth: Se)
Chain Length:145
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A2Y9E7Q1 Pfam ID:PF01090

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S20
Gene (Uniprot):RPS20
Chain IDs:YB (auth: Sf)
Chain Length:119
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SIZ2 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein eS21
Chain IDs:ZB (auth: Sg)
Chain Length:83
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A1Z5KTU7 Pfam ID:PF01249

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S15a
Gene (Uniprot):RPS15A
Chain IDs:AC (auth: Sh)
Chain Length:130
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TG89 Pfam ID:PF00410

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S23
Gene (Uniprot):RPS23
Chain IDs:BC (auth: Si)
Chain Length:143
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SZ47 Pfam ID:PF00164

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S24
Gene (Uniprot):RPS24
Chain IDs:CC (auth: Sj)
Chain Length:130
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A6J1UT65 Pfam ID:PF01282

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S25
Gene (Uniprot):RPS25
Chain IDs:DC (auth: Sk)
Chain Length:124
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A2U4BVW1 Pfam ID:PF03297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L41
Gene (Uniprot):RPL41
Chain IDs:EC (auth: Sl)
Chain Length:25
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A087WNH4 Pfam ID:PF05162

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details
6MZ	WA	A	modified residue
7MG	WA	G	modified residue
A2M	WA	A	modified residue
AME	ZB	MET	modified residue
AYA	H	ALA	modified residue
GTP	D	G	modified residue
HIC	G	HIS	modified residue
HY3	BC	PRO	modified residue
M3L	QA	LYS	modified residue
MA6	WA	A	modified residue
MLZ	FA, RA	LYS	modified residue
NMM	XB	ARG	modified residue
OMC	WA	C	modified residue
OMG	E, WA	G	modified residue
OMU	WA	U	modified residue
PSU	E, WA	U	modified residue
SAC	TA, EB, WB	SER	modified residue

Ligand Molecules

Primary Citation

Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.

Hilal, T, Killam, B.Y, Grozdanovic, M, Dobosz-Bartoszek, M, Loerke, J, Burger, J, Mielke, T, Copeland, P.R, Simonovic, M, Spahn, C.M.T.Show

Science 376 1338 1343 (2022)

PMID: 35709277 DOI: 10.1126/science.abg3875

Abstact

The elongation of eukaryotic selenoproteins relies on a poorly understood process of interpreting in-frame UGA stop codons as selenocysteine (Sec). We used cryo-electron microscopy to visualize Sec UGA recoding in mammals. A complex between the noncoding Sec-insertion sequence (SECIS), SECIS-binding protein 2 (SBP2), and 40S ribosomal subunit enables Sec-specific elongation factor eEFSec to deliver Sec. eEFSec and SBP2 do not interact directly but rather deploy their carboxyl-terminal domains to engage with the opposite ends of the SECIS. By using its Lys-rich and carboxyl-terminal segments, the ribosomal protein eS31 simultaneously interacts with Sec-specific transfer RNA (tRNASec) and SBP2, which further stabilizes the assembly. eEFSec is indiscriminate toward l-serine and facilitates its misincorporation at Sec UGA codons. Our results support a fundamentally distinct mechanism of Sec UGA recoding in eukaryotes from that in bacteria.

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Primary Citation of related structures

Abstact

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