37IC image
Deposition Date 2026-07-21
Release Date 2026-11-11
Last Version Date 2026-11-11
Entry Detail
PDB ID:
37IC
Keywords:
CYTOSOLIC PROTEIN
Title:
Doc2b-Munc13 complex with designed binder
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Rattus norvegicus (Taxon ID: 10116)
Expression System(s):
Escherichia coli 'bl21-gold(de3)plyss ag'
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.94 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
37IC validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Designed binder,Double C2-lik
Gene (Uniprot):Doc2b
Chain IDs:A
Chain Length:231
Number of Molecules:1
Biological Source:synthetic construct, Rattus norvegicus
UniProt ID:P70610
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Unc-13 homolog A
Gene (Uniprot):Unc13a
Chain IDs:B
Chain Length:1147
Number of Molecules:1
Biological Source:Rattus norvegicus
UniProt ID:A0ABK0KWN4
Ligand Molecules
NA
Primary Citation
Cryo-EM and NMR Reveal a Membrane-Gated Doc2B-Munc13-1 Complex and a Helical Doc2B-SNARE-Binding Interface.
Adv Sci ? ? ? (2026)
PMID: 42973246 DOI: 10.1002/advs.78011
Primary Citation of related structures
37IC
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