12DK image
Deposition Date 2026-03-28
Release Date 2026-05-06
Last Version Date 2026-05-06
Entry Detail
PDB ID:
12DK
Keywords:
MEMBRANE PROTEIN
Title:
structure of human KCNQ1-CaM-PIP2 intermediate state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.47 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
12DK validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Potassium voltage-gated chann
Gene (Uniprot):KCNQ1
Mutagens:I145C, E160R, R231E
Chain IDs:A, F (auth: C), G (auth: E), H (auth: G)
Chain Length:545
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P51787 Pfam ID:PF00520, PF03520
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Calmodulin-1
Gene (Uniprot):CALM1
Chain IDs:B, C (auth: D), D (auth: F), E (auth: H)
Chain Length:149
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P0DP23 Pfam ID:PF13499
Ligand Molecules
CA
PT5
Primary Citation
PIP2 activation of the cardiac IKs potassium channel
To Be Published ? ? ? (?)
Primary Citation of related structures
12DK
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