ISDA: 11WD

Deposition Date 2026-03-15

Release Date 2026-09-23

Last Version Date 2026-09-23

Entry Detail

PDB ID:

11WD

Keywords:

MEMBRANE PROTEIN

Title:

GluA2-STZ desensitized state with full agonist glutamate (Glu) at 25 degrees C (full-length composite)

Biological Source:

Source Organism(s):

Rattus norvegicus (Taxon ID: 10116)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.69 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform Flip of Glutamate rec
Gene (Uniprot):Cacng2, Gria2
Chain IDs:A, B, C, D
Chain Length:1051
Number of Molecules:4
Biological Source:Rattus norvegicus, Mus musculus

UniProt ID:P19491,O88602 Pfam ID:PF01094, PF10613, PF00060, PF00822

Ligand Molecules

GLU

POV

Primary Citation

Pre-activation and gating pathway of AMPA receptors revealed by full and partial agonists.

Newton, T.P, Aktolun, M, Yelshanskaya, M.V, Alekseev, A.A, Yen, L.Y, Gangwar, S.P, Sobolevsky, I.A, Kurnikova, M.G, Sobolevsky, A.I.Show

Nat.Struct.Mol.Biol. ? ? ? (2026)

PMID: 42717062 DOI: 10.1038/s41594-026-01882-9

Primary Citation of related structures

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