ISDA: 10MT

Deposition Date 2026-01-28

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

10MT

Keywords:

HYDROLASE

Title:

C2 symmetry expanded and subtracted 20S Proteasome, Blm10, Fub1 Complex Halfmer

Biological Source:

Source Organism(s):

Saccharomyces cerevisiae S288C (Taxon ID: 559292)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.70 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):SCL1
Chain IDs:A
Chain Length:252
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P21243 Pfam ID:PF10584, PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PRE8
Chain IDs:B
Chain Length:250
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P23639 Pfam ID:PF10584, PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PRE6
Chain IDs:L (auth: C), N (auth: D)
Chain Length:254
Number of Molecules:2
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P40303 Pfam ID:PF10584, PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome activator BLM10
Gene (Uniprot):BLM10
Chain IDs:M (auth: CA)
Chain Length:2167
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P43583 Pfam ID:PF16547, PF16507, PF23096, PF11919

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PUP2
Chain IDs:O (auth: E)
Chain Length:260
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P32379 Pfam ID:PF10584, PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PRE5
Chain IDs:C (auth: F)
Chain Length:234
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P40302 Pfam ID:PF10584, PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PRE10
Chain IDs:D (auth: G)
Chain Length:288
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P21242 Pfam ID:PF10584, PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PRE3
Chain IDs:E (auth: H)
Chain Length:215
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P38624 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PUP1
Chain IDs:F (auth: I)
Chain Length:261
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P25043 Pfam ID:PF00227, PF12465 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PUP3
Chain IDs:G (auth: J)
Chain Length:205
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P25451 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PRE1
Chain IDs:H (auth: K)
Chain Length:198
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P22141 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PRE2
Chain IDs:I (auth: L)
Chain Length:287
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P30656 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PRE7
Chain IDs:J (auth: M)
Chain Length:241
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P23724 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PRE4
Chain IDs:K (auth: N)
Chain Length:266
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P30657 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Silencing boundary-establishm
Gene (Uniprot):FUB1
Chain IDs:P (auth: a), Q (auth: b)
Chain Length:252
Number of Molecules:2
Biological Source:Saccharomyces cerevisiae S288C

UniProt ID:P25659 Pfam ID:PF08577

Ligand Molecules

Primary Citation

Blm10 and PI31 Compromise a Failsafe Mechanism for Proteasome Inhibition

Darlene, F, Rawson, S, Walsh Jr, R.M, Fermin Perez, E, Venclovaite, U, Velez, B, Rajakumar, T, Hanna, J.Show

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Primary Citation of related structures

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