Search Count: 45
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Highly Optimized Cns Penetrant Inhibitors Of Egfr Exon20 Insertion Mutations
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.42 Å Release Date: 2025-02-12 Classification: SIGNALING PROTEIN Ligands: A1IZ7 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-02-12
Ligands: A1IZ7
 |
Highly Optimized Cns Penetrant Inhibitors Of Egfr Exon20 Insertion Mutations
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.91 Å Release Date: 2025-02-12 Classification: SIGNALING PROTEIN Ligands: A1IZ8, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-02-12
Ligands: A1IZ8, SO4
 |
Highly Optimized Cns Penetrant Inhibitors Of Egfr Exon20 Insertion Mutations
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2025-02-12 Classification: SIGNALING PROTEIN Ligands: A1IZ9 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-02-12
Ligands: A1IZ9
 |
Highly Optimized Cns Penetrant Inhibitors Of Egfr Exon20 Insertion Mutations
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.22 Å Release Date: 2025-02-12 Classification: SIGNALING PROTEIN Ligands: Q6K, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-02-12
Ligands: Q6K, SO4
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Highly Optimized Cns Penetrant Inhibitors Of Egfr Exon20 Insertion Mutations. Compound 51 Bound To Egfrinsnpg [V948R]
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.45 Å Release Date: 2025-02-05 Classification: SIGNALING PROTEIN Ligands: A1IUK |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-02-05
Ligands: A1IUK
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Optimisation Of Potent, Efficacious, Selective And Blood-Brain Barrier Penetrating Inhibitors Targeting Egfr Exon20 Insertion Mutations
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.44 Å Release Date: 2024-11-06 Classification: SIGNALING PROTEIN Ligands: A1H7N, IOD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-11-06
Ligands: A1H7N, IOD
 |
Optimisation Of Potent, Efficacious, Selective And Blood-Brain Barrier Penetrating Inhibitors Targeting Egfr Exon20 Insertion Mutations
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.02 Å Release Date: 2024-10-16 Classification: SIGNALING PROTEIN Ligands: A1H7O |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-10-16
Ligands: A1H7O
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Discovery Of A Series Of Covalent, Cell Active Bfl-1 Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2024-10-02 Classification: APOPTOSIS Ligands: A1IDP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-10-02
Ligands: A1IDP
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Discovery Of A Series Of Covalent, Cell Active Bfl-1 Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.68 Å Release Date: 2024-10-02 Classification: APOPTOSIS Ligands: A1IDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-10-02
Ligands: A1IDO
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Discovery Of A Series Of Covalent, Cell Active Bfl-1 Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.94 Å Release Date: 2024-10-02 Classification: APOPTOSIS Ligands: A1IDG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-10-02
Ligands: A1IDG
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Compound 1A Bound Kmt9 Crystal Structure
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.39 Å Release Date: 2024-09-11 Classification: TRANSFERASE Ligands: SDU |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-09-11
Ligands: SDU
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Compound 1B Bound Kmt9 Crystal Structure
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.47 Å Release Date: 2024-09-11 Classification: TRANSFERASE Ligands: QII |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-09-11
Ligands: QII
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E3 Ligase Cbl-B In Complex With A Triazolone Core Inhibitor (Compound 1)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.79 Å Release Date: 2024-07-31 Classification: LIGASE Ligands: A1IEW, ZN, NA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-07-31
Ligands: A1IEW, ZN, NA
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E3 Ligase Cbl-B In Complex With A Lactam Scaffold Inhibitor (Compound 7)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2024-07-31 Classification: LIGASE Ligands: A1IEV, ZN, NA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-07-31
Ligands: A1IEV, ZN, NA
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E3 Ligase Cbl-B In Complex With A Carbamate Scaffold Inhibitor (Compound 12)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2024-07-31 Classification: LIGASE Ligands: A1IE5, ZN, NA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-07-31
Ligands: A1IE5, ZN, NA
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Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 16 Bound To Egfr
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.51 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 2I0 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 2I0
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Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 12 Bound To Egfrinsnpg
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.52 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 2I6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 2I6
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Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 22 Bound To Egfrinsnpg [V948R]
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.11 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 2EI, IOD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 2EI, IOD
 |
Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 33 Bound To Egfrinsnpg [V948R]
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.28 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 26X |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 26X
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Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 18 Bound To Egfr[V948R]
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.13 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 2II |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 2II