8QDI image
Deposition Date 2023-08-29
Release Date 2024-09-11
Last Version Date 2026-03-25
Entry Detail
PDB ID:
8QDI
Keywords:
TRANSFERASE
Title:
compound 1b bound KMT9 crystal structure
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.47 Å
R-Value Free:
0.19
R-Value Work:
0.15
Space Group:
P 61 2 2
8QDI validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Methyltransferase N6AMT1
Gene (Uniprot):HEMK2
Chain IDs:A
Chain Length:203
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y5N5 Pfam ID:PF05175 EC:2.1.1.137
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Multifunctional methyltransfe
Gene (Uniprot):TRMT112
Chain IDs:B
Chain Length:126
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UI30 Pfam ID:PF03966
Ligand Molecules
QII
Primary Citation
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity.
Nat Commun 15 43 43 (2024)
PMID: 38167811 DOI: 10.1038/s41467-023-44243-6
Primary Citation of related structures
8QDI
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