Search Count: 61
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Complex With Compound 15 ((3'R)-1'-(5-Amino-1-Phenyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.66 Å Release Date: 2026-04-01 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6X, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-04-01
Ligands: MES, A1C6X, NAG
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N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: A1C6O |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: A1C6O
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasmakallikrein Inhibitors Complex With Compound 4 ((3'R)-1'-(5-Amino-1-Benzyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Q, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: MES, A1C6Q, NAG
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 25 ((3'R)-1'-{(1P)-5-Amino-1-[2-(Trifluoromethoxy)Phenyl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Z, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: MES, A1C6Z, NAG
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-Amino-1-[(2S)-1,1,1-Trifluorobutan-2-Yl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C7M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: MES, A1C7M
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Crystal Structure Of Gel4 In Complex With Nanobody 4
Organism: Aspergillus fumigatus af293, Vicugna pacos
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2024-06-19 Classification: TRANSFERASE Ligands: NAG, MAN |
Organism: Aspergillus fumigatus af293, Vicugna pacos
Method: X-RAY DIFFRACTION
Release Date: 2024-06-19
Ligands: NAG, MAN
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Crystal Structure Of Gel4 In Complex With Nanobody 3
Organism: Aspergillus fumigatus, Vicugna pacos
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2024-06-19 Classification: TRANSFERASE Ligands: NAG, MAN, PO4 |
Organism: Aspergillus fumigatus, Vicugna pacos
Method: X-RAY DIFFRACTION
Release Date: 2024-06-19
Ligands: NAG, MAN, PO4
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Crystal Structure Of The N-Terminal Kinase Domain Of Rsk2 In Complex With Spred2 (131-160)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2023-04-26 Classification: TRANSFERASE Ligands: QCT |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-04-26
Ligands: QCT
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Sars-Cov-2 Wuhan-Hu-1-Spike-Rbd Bound To Linker Variant Of Affinity Matured Ace2 Mimetic Cvd432
Organism: Severe acute respiratory syndrome coronavirus 2, Homo sapiens
Method: ELECTRON MICROSCOPY Release Date: 2022-08-31 Classification: VIRAL PROTEIN/ANTIVIRAL PROTEIN Ligands: NAG |
Organism: Severe acute respiratory syndrome coronavirus 2, Homo sapiens
Method: ELECTRON MICROSCOPY
Release Date: 2022-08-31
Ligands: NAG
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Sars-Cov-2 Wuhan-Hu-1-Spike-Rbd Bound To Computationally Engineered Ace2 Mimetic Cvd293
Organism: Severe acute respiratory syndrome coronavirus 2, Homo sapiens
Method: ELECTRON MICROSCOPY Release Date: 2022-08-31 Classification: VIRAL PROTEIN/ANTIVIRAL PROTEIN Ligands: NAG |
Organism: Severe acute respiratory syndrome coronavirus 2, Homo sapiens
Method: ELECTRON MICROSCOPY
Release Date: 2022-08-31
Ligands: NAG
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Structure Of A Complement Factor-Receptor Complex
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.40 Å Release Date: 2022-04-13 Classification: IMMUNE SYSTEM Ligands: GOL, K, MG, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-04-13
Ligands: GOL, K, MG, NAG
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Crystal Structure Of The Capsaspora Owczarzaki Macroh2A Macrodomain
Organism: Capsaspora owczarzaki (strain atcc 30864)
Method: X-RAY DIFFRACTION Resolution:1.34 Å Release Date: 2021-11-24 Classification: NUCLEAR PROTEIN Ligands: EDO, PEG |
Organism: Capsaspora owczarzaki (strain atcc 30864)
Method: X-RAY DIFFRACTION
Release Date: 2021-11-24
Ligands: EDO, PEG
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Crystal Structure Of The Capsaspora Owczarzaki Macroh2A Macrodomain In Complex With Adp-Ribose
Organism: Capsaspora owczarzaki (strain atcc 30864)
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2021-11-24 Classification: NUCLEAR PROTEIN Ligands: EDO, APR |
Organism: Capsaspora owczarzaki (strain atcc 30864)
Method: X-RAY DIFFRACTION
Release Date: 2021-11-24
Ligands: EDO, APR
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Bace-1 In Complex With Compound #6
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.25 Å Release Date: 2021-07-21 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: ZQS, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-07-21
Ligands: ZQS, GOL
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Bace-1 In Complex With Compound #22
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.94 Å Release Date: 2021-07-21 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: ZR7, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-07-21
Ligands: ZR7, SO4
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Bace-1 In Complex With Compound #18
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.72 Å Release Date: 2021-07-14 Classification: HYDROLASE Ligands: ZRD, GOL, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-07-14
Ligands: ZRD, GOL, SO4
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The Structure Of Eanb Complex With Hercynine And Persulfided Cys412
Organism: Chlorobium limicola
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2020-08-26 Classification: TRANSFERASE Ligands: AVJ, MG, CL, GOL, EDO, PEG, PG4, PDO, IMD, NI |
Organism: Chlorobium limicola
Method: X-RAY DIFFRACTION
Release Date: 2020-08-26
Ligands: AVJ, MG, CL, GOL, EDO, PEG, PG4, PDO, IMD, NI
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Structure Of Eanb With Hercynine
Organism: Chlorobium limicola
Method: X-RAY DIFFRACTION Resolution:1.93 Å Release Date: 2020-08-26 Classification: TRANSFERASE Ligands: MG, AVJ, CL, PGE, GOL, IMD, NA, EDO |
Organism: Chlorobium limicola
Method: X-RAY DIFFRACTION
Release Date: 2020-08-26
Ligands: MG, AVJ, CL, PGE, GOL, IMD, NA, EDO
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The Wildtype Structure Of Eanb
Organism: Chlorobium limicola
Method: X-RAY DIFFRACTION Resolution:2.19 Å Release Date: 2020-08-26 Classification: TRANSFERASE Ligands: MG, CL, PEG, MPO, EDO, PGE |
Organism: Chlorobium limicola
Method: X-RAY DIFFRACTION
Release Date: 2020-08-26
Ligands: MG, CL, PEG, MPO, EDO, PGE
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The Complex Structure Of Eanb/C412S With Hercynine
Organism: Chlorobium limicola
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2020-08-26 Classification: TRANSFERASE Ligands: MG, AVJ, PEG, EDO, CL, BR |
Organism: Chlorobium limicola
Method: X-RAY DIFFRACTION
Release Date: 2020-08-26
Ligands: MG, AVJ, PEG, EDO, CL, BR