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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Complex With Compound 15 ((3'R)-1'-(5-Amino-1-Phenyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.66 Å Release Date: 2026-04-01 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6X, NAG |
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N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: A1C6O |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasmakallikrein Inhibitors Complex With Compound 4 ((3'R)-1'-(5-Amino-1-Benzyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Q, NAG |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 25 ((3'R)-1'-{(1P)-5-Amino-1-[2-(Trifluoromethoxy)Phenyl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Z, NAG |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-Amino-1-[(2S)-1,1,1-Trifluorobutan-2-Yl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C7M |
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Crystal Structure Of The Sars-Cov-2 Neutralizing Vhh 7A9 Bound To The Spike Receptor Binding Domain
Organism: Severe acute respiratory syndrome coronavirus 2, Lama glama
Method: X-RAY DIFFRACTION Resolution:2.01 Å Release Date: 2023-08-16 Classification: ANTIVIRAL PROTEIN |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.08 Å Release Date: 2023-06-14 Classification: SIGNALING PROTEIN Ligands: PCG, ATP, EDO, CL |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.99 Å Release Date: 2023-06-14 Classification: TRANSFERASE Ligands: EX6 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.28 Å Release Date: 2023-06-14 Classification: TRANSFERASE Ligands: EXZ, CL |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.23 Å Release Date: 2023-06-14 Classification: TRANSFERASE Ligands: EZJ, CL |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.40 Å Release Date: 2022-08-24 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: B4I |
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Crystal Structure Of Hla A*2402 In Complex With Tyqwvlknl, An 9-Mer Epitope From Influenza B Virus
Organism: Homo sapiens, Influenza b virus
Method: X-RAY DIFFRACTION Resolution:2.16 Å Release Date: 2021-04-14 Classification: IMMUNE SYSTEM Ligands: MG |
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Crystal Structure Of Hla-A*2402 In Complex With Iyfspirvtf, An 10-Mer Epitope From Influenza B Virus
Organism: Homo sapiens, Influenza a virus
Method: X-RAY DIFFRACTION Resolution:2.75 Å Release Date: 2021-04-14 Classification: IMMUNE SYSTEM Ligands: MG |
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Crystal Structure Of Hla A*2402 In Complex With Yfspirvtf, An 9-Mer Influenza Epitope
Organism: Homo sapiens, Influenza b virus
Method: X-RAY DIFFRACTION Resolution:1.51 Å Release Date: 2021-04-14 Classification: IMMUNE SYSTEM Ligands: MG |
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Crystal Structure Of Hla A*2402 In Complex With Tyqwiirnw, An 9-Mer Influenza Epitope
Organism: Homo sapiens, Influenza a virus
Method: X-RAY DIFFRACTION Resolution:2.90 Å Release Date: 2021-04-14 Classification: IMMUNE SYSTEM Ligands: CA, NA, NI |
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Crystal Structure Of Hla A*2402 In Complex With Tyqwiirnwet, An 11-Mer Epitope From Influenza
Organism: Homo sapiens, Influenza a virus
Method: X-RAY DIFFRACTION Resolution:2.95 Å Release Date: 2021-04-14 Classification: IMMUNE SYSTEM |
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Crystal Structure Of Hla-A*68:01 In Complex With Np145-156, A 12 Mer Influenza Peptide
Organism: Homo sapiens, Unidentified influenza virus
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2019-12-11 Classification: IMMUNE SYSTEM Ligands: IOD, MG, SO4 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2019-12-11 Classification: APOPTOSIS/INHIBITOR Ligands: Q57 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2019-12-11 Classification: APOPTOSIS/INHIBITOR Ligands: Q54 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2019-12-04 Classification: APOPTOSIS/INHIBITOR Ligands: Q4D |