ISDA: 9ZUK

Deposition Date 2025-12-24

Release Date 2026-09-16

Last Version Date 2026-11-11

Entry Detail

PDB ID:

9ZUK

Keywords:

GENE REGULATION

Title:

Crystal structure of BPTF bromodomain bound to BZ1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.35 Å

R-Value Free:

0.19

R-Value Work:

0.15

R-Value Observed:

0.15

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nucleosome-remodeling factor
Gene (Uniprot):BPTF
Chain IDs:A, B
Chain Length:123
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q12830

Ligand Molecules

A1C4C

Primary Citation

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma.

Babu, K, Tsou, C.J, Das, S, Fan, L, Pal, A, Sneddon, M, Stachowski, T.R, Samanta, P, Nithianantham, S, Buchholz, C, Zhang, S, Fu, X, Kathayat, R.S, Lin, W, Li, Y, Yang, L, Chen, T, Fischer, M, Shelat, A.A, Pomerantz, W.C.K.Show

Angew.Chem.Int.Ed.Engl. 65 ? ? (2026)

PMID: 42711825 DOI: 10.1002/anie.4580510

Primary Citation of related structures

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