ISDA: 9ZU4

Deposition Date 2025-12-23

Release Date 2026-09-16

Last Version Date 2026-11-11

Entry Detail

PDB ID:

9ZU4

Keywords:

GENE REGULATION

Title:

Crystal structure of BRD9 bromodomain bound to BZ2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.05 Å

R-Value Free:

0.14

R-Value Work:

0.12

R-Value Observed:

0.12

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bromodomain-containing protei
Gene (Uniprot):BRD9
Chain IDs:A
Chain Length:129
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9H8M2

Ligand Molecules

XHK

Primary Citation

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma.

Babu, K, Tsou, C.J, Das, S, Fan, L, Pal, A, Sneddon, M, Stachowski, T.R, Samanta, P, Nithianantham, S, Buchholz, C, Zhang, S, Fu, X, Kathayat, R.S, Lin, W, Li, Y, Yang, L, Chen, T, Fischer, M, Shelat, A.A, Pomerantz, W.C.K.Show

Angew.Chem.Int.Ed.Engl. 65 ? ? (2026)

PMID: 42711825 DOI: 10.1002/anie.4580510

Primary Citation of related structures

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