ISDA: 9ZQ7

Deposition Date 2025-12-17

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9ZQ7

Keywords:

SIGNALING PROTEIN

Title:

Autoinhibited P-Rex2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

5.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Phosphatidylinositol 3,4,5-tr
Gene (Uniprot):PREX2
Chain IDs:A
Chain Length:1621
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q70Z35 Pfam ID:PF00621, PF22697, PF00610, PF00595

Ligand Molecules

Primary Citation

The Rho guanine-nucleotide exchange factor P-Rex2 exhibits structural and regulatory features distinct from the related RhoGEF P-Rex1.

Anderson, L.K, Marde, R, Muma, G, Nayak, V, Phan, C, Li, S, Cash, J.N.Show

J.Biol.Chem. 302 113229 113229 (2026)

PMID: 42248461 DOI: 10.1016/j.jbc.2026.113229

Primary Citation of related structures

Feedback Form