9ZND image
Deposition Date 2025-12-12
Release Date 2026-09-16
Last Version Date 2026-09-16
Entry Detail
PDB ID:
9ZND
Title:
Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
3.09 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Ryanodine receptor 1
Gene (Uniprot):RYR1
Chain IDs:I (auth: D), J (auth: B), K (auth: A), L (auth: C)
Chain Length:5037
Number of Molecules:4
Biological Source:Oryctolagus cuniculus
Polymer Type:polypeptide(L)
Molecule:Peptidyl-prolyl cis-trans iso
Gene (Uniprot):FKBP1B
Chain IDs:A (auth: E), B (auth: F), C (auth: G), D (auth: H)
Chain Length:107
Number of Molecules:4
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Calmodulin-1
Gene (Uniprot):CALM1
Chain IDs:E (auth: I), F (auth: J), G (auth: K), H (auth: L)
Chain Length:148
Number of Molecules:4
Biological Source:Homo sapiens
Primary Citation
Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene
Nat Commun ? ? ? (2026)
DOI: 10.1038/s41467-026-76519-y
Primary Citation of related structures
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