9ZKG image
Deposition Date 2025-12-06
Release Date 2026-04-29
Last Version Date 2026-04-29
Entry Detail
PDB ID:
9ZKG
Keywords:
TRANSFERASE/TRANSFERASE INHIBITOR
Title:
VRK1 in complex with the inhibitor MP-60
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.06 Å
R-Value Free:
0.21
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
P 21 21 21
9ZKG validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):VRK1
Mutagens:M1A, M2P, K34A, K35A, E36A, E212A, K214A, E215A, E292A, K293A, K295A, K359A, K360A
Chain IDs:A, B, C, D
Chain Length:364
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q99986
Ligand Molecules
A1C2O
ACN
CL
EDO
GG0
GOL
PEG
SO4
Primary Citation
Structure-Based Discovery of Selective Vaccinia-Related Kinase 1 Inhibitors and Fluorogenic Active-Site Probes.
J.Biol.Chem. ? 111355 111355 (2026)
PMID: 41796804 DOI: 10.1016/j.jbc.2026.111355
Primary Citation of related structures
9ZKG
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