ISDA: 9ZKC

Deposition Date 2025-12-05

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9ZKC

Keywords:

MEMBRANE PROTEIN

Title:

Structure of RY12 domain of rabbit RyR1 in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions; unbound and open RY12)

Biological Source:

Source Organism(s):

Oryctolagus cuniculus (Taxon ID: 9986)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.66 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ryanodine receptor 1
Gene (Uniprot):RYR1
Chain IDs:A
Chain Length:208
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:P11716 Pfam ID:PF02026

Ligand Molecules

Primary Citation

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Kim, K, Li, H, Yuan, Q, Melville, Z, Zalk, R, des Georges, A, Frank, J, Hendrickson, W.A, Marks, A.R, Clarke, O.B.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-76519-y

Primary Citation of related structures

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