ISDA: 9Z7B

Deposition Date 2025-11-16

Release Date 2026-06-03

Last Version Date 2026-06-03

Entry Detail

PDB ID:

9Z7B

Keywords:

HYDROLASE/IMMUNE SYSTEM

Title:

Cryo-EM structure of Protein involved in colonization (Pic) from Enteroaggregative Escherichia coli complexed with the fragment antigen binding domain of monoclonal antibody 40

Biological Source:

Source Organism(s):

Escherichia coli 042 (Taxon ID: 216592)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli 042, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.69 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine protease pic autotrans
Gene (Uniprot):pic
Chain IDs:A
Chain Length:1040
Number of Molecules:1
Biological Source:Escherichia coli 042

UniProt ID:Q7BS42 EC:3.4.21.-

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Heavy chain of the fragment a
Chain IDs:B
Chain Length:224
Number of Molecules:1
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Light chain of the fragment a
Chain IDs:C
Chain Length:215
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Human infection with enterotoxigenic E. coli elicits antibodies that broadly neutralize mucin-degrading proteases of pathogenic E. coli and Shigella

Buckley, D.P, Akhtar, M, Thapa, M, Schmitz, A, Turner, J, Vickers, T.J, Khatoon, N, Kaisar, H, Coggin, J.A, Ganguli, D, Sheikh, A, Laird, R.M, Poly, F, Porter, C.K, Ruiz-Perez, F, Miller, M.J, Bhuiyan, T.R, Qadri, F, Trillo-Muyo, S, Dolan, B, van der Post, S, Ellebedy, A, Berndsen, Z.T, Fleckenstein, J.M.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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