ISDA: 9Z5Z

Deposition Date 2025-11-13

Release Date 2026-10-21

Last Version Date 2026-10-21

Entry Detail

PDB ID:

9Z5Z

Keywords:

METAL BINDING PROTEIN

Title:

Co-crystal structure of compound 3S bound to the Catalytic domain of human PAH

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.92 Å

R-Value Free:

0.21

R-Value Work:

0.17

R-Value Observed:

0.18

Space Group:

C 2 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Phenylalanine-4-hydroxylase
Gene (Uniprot):PAH
Chain IDs:A
Chain Length:316
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00439 EC:1.14.16.1

Ligand Molecules

A1C05

EDO

Primary Citation

Discovery of a pharmacological chaperone that stabilizes mutant forms of phenylalanine hydroxylase and significantly lowers blood phenylalanine in a classical phenylketonuria mouse model

Hammoudeh, D, Padyana, A.Show

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Primary Citation of related structures

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