9Z07 image
Deposition Date 2025-10-31
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
9Z07
Keywords:
TRANSFERASE/DNA
Title:
Cryo-EM structure of DNMT1 in complex with unmethylated nucleosome core particle
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Xenopus laevis (Taxon ID: 8355)
Escherichia coli (Taxon ID: 562)
Expression System(s):
Escherichia coli bl21, Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.19 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9Z07 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA (cytosine-5)-methyltransf
Gene (Uniprot):DNMT1
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P26358 Pfam ID:PF12047, PF02008, PF01426, PF00145 EC:2.1.1.37
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Histone H2A
Gene (Uniprot):LOC494591
Chain IDs:B (auth: N), H (auth: n)
Chain Length:0
Number of Molecules:2
Biological Source:Xenopus laevis
UniProt ID:Q6AZJ8 Pfam ID:PF00125, PF16211
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Histone H2B 1.1
Chain IDs:C (auth: O), I (auth: o)
Chain Length:0
Number of Molecules:2
Biological Source:Xenopus laevis
UniProt ID:P02281 Pfam ID:PF00125
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Histone H3
Gene (Uniprot):LOC121398065
Chain IDs:D (auth: P), J (auth: p)
Chain Length:0
Number of Molecules:2
Biological Source:Xenopus laevis
UniProt ID:A0A310TTQ1 Pfam ID:PF00125
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Histone H4
Chain IDs:E (auth: Q), K (auth: q)
Chain Length:0
Number of Molecules:2
Biological Source:Xenopus laevis
UniProt ID:P62799 Pfam ID:PF15511
Polymer Type:polydeoxyribonucleotide
Molecule:Chain x DNA (149-MER)
Chain IDs:F (auth: X)
Chain Length:0
Number of Molecules:1
Biological Source:Escherichia coli
Polymer Type:polydeoxyribonucleotide
Molecule:Chain Y DNA (149-MER)
Chain IDs:G (auth: Y)
Chain Length:0
Number of Molecules:1
Biological Source:Escherichia coli
Ligand Molecules
ZN
Primary Citation
The DNMT1 CXXC domain senses CpG islands for DNA methylation inhibition
To Be Published ? ? ? (2026)
Primary Citation of related structures
9Z07
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