ISDA: 9YUB

Deposition Date 2025-10-22

Release Date 2026-10-28

Last Version Date 2026-11-11

Entry Detail

PDB ID:

9YUB

Keywords:

TRANSFERASE/INHIBITOR

Title:

The crystal structure of human abl1 T315I mutant kinase domain in complex with PH-ELV-1022

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.24

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase ABL1
Gene (Uniprot):ABL1
Mutagens:T315I
Chain IDs:A
Chain Length:290
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00519 EC:2.7.10.2

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
PTR	A	TYR	modified residue

Ligand Molecules

A1CZ6

Primary Citation

Relcobatinib, a highly selective ATP-competitive ABL1 tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia.

Gross, S.D, Eide, C.A, Burkard, M.R, Reister Schultz, A, Chao, A, DuPrez, K.T, Han, F, Broad, A.J, Reuther, D, Zhang, Y, Aslan, J.E, McCarty, O.J.T, Aujay, M.A, Kintz, S, Druker, B.J, Lyssikatos, J.P.Show

Leukemia ? ? ? (2026)

PMID: 42977784 DOI: 10.1038/s41375-026-03184-x

Primary Citation of related structures

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