9YOV image
Deposition Date 2025-10-13
Release Date 2026-07-29
Last Version Date 2026-07-29
Entry Detail
PDB ID:
9YOV
Title:
Cryo-EM structure of an active dimer of the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion bound to LIN-3.
Biological Source:
Source Organism(s):
Method Details:
Experimental Method:
Resolution:
3.36 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Receptor tyrosine-protein kin
Gene (Uniprot):let-23
Chain IDs:A, C (auth: B)
Chain Length:792
Number of Molecules:2
Biological Source:Caenorhabditis elegans
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein spitz,Protein lin-3
Gene (Uniprot):spi, lin-3
Chain IDs:B (auth: C), D
Chain Length:104
Number of Molecules:2
Biological Source:Caenorhabditis elegans
Ligand Molecules
Primary Citation
Ligand regulation and function of preformed EGFR dimers
Proc.Natl.Acad.Sci.USA ? ? ? (2026)
DOI: 10.1073/pnas.2602436123
Primary Citation of related structures
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