ISDA: 9YJN

Deposition Date 2025-10-03

Release Date 2026-09-09

Last Version Date 2026-09-09

Entry Detail

PDB ID:

9YJN

Keywords:

LIGASE

Title:

Trypanosoma cruzi Lysyl-tRNA synthetase in complex with L-Lysine

Biological Source:

Source Organism(s):

Trypanosoma cruzi Dm28c (Taxon ID: 1416333)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.08 Å

R-Value Free:

0.24

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 43 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lysine--tRNA ligase
Gene (Uniprot):TCDM_08178
Chain IDs:A
Chain Length:580
Number of Molecules:1
Biological Source:Trypanosoma cruzi Dm28c

UniProt ID:V5ASS1 Pfam ID:PF01336, PF00152 EC:6.1.1.6

Ligand Molecules

LYS

Primary Citation

In Vivo Efficacy and Biochemical

dos Santos, T.C.F, de Lima Silva, C.C, Eufraasio, A.G, Tambascia, C, De Sousa, I.L, Marchese, L, Catelli, M.F, de Almeida, L.R, Costa Venancio, G.D, de Souza, V.B, Schenka, A.A, Rocco, S.A, Mercaldi, G.F, Cordeiro, A.T.Show

J.Med.Chem. ? ? ? (2026)

DOI: 10.1021/acs.jmedchem.6c00764

Primary Citation of related structures

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