9YF2 image
Deposition Date 2025-09-25
Release Date 2026-09-30
Last Version Date 2026-09-30
Entry Detail
PDB ID:
9YF2
Keywords:
ONCOPROTEIN
Title:
Crystal structure of PI3Ka H1047R mutant in complex with PRT7140 in allosteric pocket
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Baculovirus expression vector pfastbac1-hm
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.61 Å
R-Value Free:
0.29
R-Value Work:
0.23
R-Value Observed:
0.24
Space Group:
P 1 21 1
9YF2 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Phosphatidylinositol 4,5-bisp
Gene (Uniprot):PIK3CA
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P42336 Pfam ID:PF02192, PF00794, PF00792, PF00613, PF00454 EC:2.7.1.137
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Phosphatidylinositol 3-kinase
Gene (Uniprot):PIK3R1
Chain IDs:B (auth: C)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P27986 Pfam ID:PF00017, PF16454 EC:2.7.1.153
Ligand Molecules
A1CV8
X3N
Primary Citation
Discovery of Tetrasubstituted Quinazolin-4(3 H )-ones as Wild-type-sparing, Highly Selective PI3K alpha H1047R Inhibitors
J.Med.Chem. ? ? ? (2026)
DOI: 10.1021/acs.jmedchem.6c00269
Primary Citation of related structures
9YF2
Feedback Form
Name
Email
Institute
Feedback