ISDA: 9YCQ

Deposition Date 2025-09-19

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9YCQ

Keywords:

TRANSCRIPTION/INHIBITOR

Title:

First Bromodomain of BRDT liganded with inhibitor GXH-IV-076 (compound 33)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.40 Å

R-Value Free:

0.20

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bromodomain testis-specific p
Gene (Uniprot):BRDT
Chain IDs:A, B
Chain Length:110
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q58F21 Pfam ID:PF00439

Ligand Molecules

EDO

ZNJ

Primary Citation

Structural Basis for BD1-Preferring 2,4-Disubstituted Pyrimidine BRDT Inhibitors.

Liang, T, Guan, X, Chan, A, Kalra, P, Shi, R, Solberg, J, Sigua, L.H, Qi, J, Pomerantz, W.C.K, Schonbrunn, E, Hawkinson, J.E, Georg, G.I.Show

J.Med.Chem. 69 11088 11108 (2026)

PMID: 41984625 DOI: 10.1021/acs.jmedchem.6c00180

Primary Citation of related structures

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